Naltrexone was developed for, and is primarily used as, a blocking agent for narcotic drugs and alcohol. It has been an effective method for treating drug and alcohol addictions for years. That is not; however, the only way Naltrexone can be used. It is also being used by some physicians, in very small dosages, as a treatment for multiple sclerosis (MS).
Naltrexone Use
Physicians using low dose Naltrexone (LDN) as a treatment of MS, can use it in several different ways. Some may use it to block the disease's progress; thereby sidestepping some of its worst side effects. Others will find it useful in relapse prevention. Still others can use it to treat MS's symptoms like depression, fatigue, inability to think cognitively, incontinence, muscle weakness and spastic movement.
How the Drug Works
No one completely understands how LDN works. Some researchers believe it increases the endorphin levels within the body, leading to a feeling of well-being. This could explain the drug's effectiveness in treating side effects , fatigue and pain. Others believe it acts like an antioxidant to reduce free radicals. These are, however, just theories. Research continues in an attempt to pin down how the drug really works.
Naltrexone's Effectiveness
Some scientific trials claim the drug can lower the nervous system inflammation associated with MS. Others claim Naltrexone increase the body's natural immunity, making the condition less severe. One study done by the University of California proved the drug's ability to decrease some of the side effects of MS. Another done in Italy suggested it increased some side effects like fatigue and pain, while decreasing others like depression and muscle spasms.
Dosage Amounts
Naltrexone can be prescribed orally or by injection. The typical dosages used for MS patients are small, averaging about 3 milligrams per day. Dosages over 5 mg are not recommended.
Naltrexone Side Effects
Because the drug is administered in small doses it produces few side effects and some disappear once the body becomes acclimated. Side effects reported include blood count fluctuation, increased cholesterol, irritability, noted change in liver function and increased or vivid dreaming.
Drug Warnings
Some things need to be avoided while taking Naltrexone. It cannot be used in combination with narcotics since the effects of using the drugs together, in the wrong combination, often produce negative results.
In some patients, Naltrexone decreases reaction time. Therefore, those using it should not operate heavy or dangerous equipment. An overdose can be fatal if it is not counteracted in time. Overdose symptoms include convulsions, dizziness, nausea and stomach pain.
Individuals taking Naltrexone should inform their physician if they drink alcohol or take narcotics; have hemophilia, kidney or liver disease, are pregnant or plan to become pregnant; or are breastfeeding.
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