Depakote is used to treat many types of seizures common in children, as well as the manic phase of bipolar disorder. It is also used to prevent migraine headaches. Its generic name is divalproex sodium. Generally, depakote is well-tolerated, but like any medicine, it has side effects, particularly in children.
Benefits
Depakote is one of the most effective treatments available for absence seizures (once known as petit mal seizures) in children. It is also effective for infantile spasms, tonic clonic seizures (once known as grand mal seizures) and seizures triggered by flashing lights.
Side Effects in Children Under 2 Years Old
Children younger than 2 years old taking depakote have a much higher rate of liver failure than adults or older the drug. The risk is higher for very young children who also take other seizure medications or have a metabolic disorder or a brain disease.
Symptoms of Liver Damage
Liver damage usually occurs within the first six months of treatment with depakote. Children experiencing liver damage have symptoms that include vomiting, loss of appetite, sluggishness and yellow skin and eyes.
Increased Levels of Testosterone in Girls
Many girls older than 10 who take depakote have unusually high levels of testosterone. The most obvious sign of this is generally weight gain. A child's pediatrician will monitor these levels.
Irritability
Some children taking depakote experience increased irritability, but it is rarely a serious problem.
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